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KMID : 0380620070390030330
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Korean Journal of Food Science and Technology
2007 Volume.39 No. 3 p.330 ~ p.335
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Physiological Activity/Nutrition : Anti-diabetic Effect of Crude Polysaccharides from Grifola frondosa in KK-Ay Diabetic Mouse and 3T3-L1 Adipocyte
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Park Kum-Ju
Oh Young-Joo
Lee Sang-Yun
Kim Hyun-Su
Ha Hyo-Cheol
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Abstract
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This study was performed to investigate the anti-diabetic mechanism of crude polysaccharides isolated from the fruiting bodies of Grifola frondosa. We treated 3T3-L1 adipocyte cells to observe whether the crude polysaccharides isolated from Grifola frondosa would stimulate insulin sensitivity. Significant insulin sensitizing activity was observed in the 3T3-L1 adipocytes, and giving the crude polysaccharide of Grifola frondosa with 1 nM of insulin caused glucose uptake to increase to a similar level as giving 50 nM of insulin alone. To confirm the mechanism for the anti-diabetic effect of the crude polysaccharides, we performed further examinations within KK-Ay mice, an animal model of type 2 diabetes. The crude polysaccharides reduced blood glucose levels in the KK-Ay mice for 2 weeks after feeding, and also significantly lowered plasma insulin levels. These results suggest that the anti-diabetic mechanism of the crude polysaccharide of Grifola frondosa is related to the enhancement of insulin sensitivity.
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KEYWORD
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Grfola frondosa, Crude polysaccharide, 3T3-L1 adipocyte, Insulin sensitivity, KK-Ay mice
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